0516 : Shear stress regulates endothelial autophagy: consequences on endothelial senescence and atherogenesis
نویسندگان
چکیده
منابع مشابه
[Role of shear stress and endothelial mechanotransduction in atherogenesis].
WSTĘP Pomiędzy krwią a ścianą naczynia zachodzi nieprzerwana interakcja, zależna od ciśnienia tętniczego i zmiennej prędkości przepływu związanej z cyklicznością pracy serca. Z przepływem wiążą się naprężenia ścinające działające na komórki śródbłonka. Odpowiedzią naczynia na nieprawidłowe naprężenia ścinające jest zmiana architektury śródbłonka i zaburzenia jego czynności. Za pośrednictwem mec...
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OBJECTIVE The proinflammatory phenotype induced by low laminar shear stress (LSS) is implicated in atherogenesis. The kinin B1 receptor (B1R), known to be induced by inflammatory stimuli, exerts many proinflammatory effects including vasodilatation and leukocyte recruitment. We investigated whether low LSS is a stimulus for endothelial B1R expression and function. METHODS AND RESULTS Human an...
متن کاملShear stress regulates endothelial microparticle release.
RATIONALE Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. OBJECTIVE Because laminar shear stress (SS) is a major physiological regulator of endothelial survival, we tested the hypothesis that SS regulates EMP release. METHODS AND RESULTS EMP levels were quantified by flow cytometry in medium of endothelial cells ...
متن کاملShear stress regulates the endothelial Kir2.1 ion channel.
Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in the early shear stress response. Here we show that an applied shear stress ind...
متن کاملInfection, endothelial dysfunction, and atherogenesis.
and Atherogenesis To the Editor: Khairy et al1 reported a lack of association between chronic infection and endothelial function in healthy young men. The study population was highly selective and, excluded women, individuals aged 45 years, and subjects with any conventional risk factors of coronary artery disease (CAD). The authors assumed that serum antibodies against the various infectious a...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2016
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(16)30364-0